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Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

20 Sept 2013

Abstract excerpt

DNA double-strand breaks (DSBs) are common lesions that continually threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including cell death. Misrepair is also fraught with danger, especially inappropriate end-joining events, which commonly underlie oncogenic transformation and can scramble the genome. Canonically, cells employ two basic mechanisms to repair DSBs: homologous...

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PMID: 24050180
DOI: 10.1146/annurev-genet-110711-155540

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