Article
Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2007
Guirouilh-Barbat Josée, Rass Emilie, Plo Isabelle, Bertrand Pascale, Lopez Bernard S
Abstract excerpt
XRCC4-null mice have a more severe phenotype than KU80-null mice. Here, we address whether this difference in phenotype is connected to nonhomologous end-joining (NHEJ). We used intrachromosomal substrates to monitor NHEJ of two distal double-strand breaks (DSBs) targeted by I-SceI, in living cells. In xrcc4-defective XR-1 cells, a residual but significant end-joining process exists, which primarily uses...
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