Article

DNA-PKcs Suppresses Illegitimate Chromosome Rearrangements

2024-01-01

Abstract excerpt

Two DNA repair pathways, non-homologous end joining (NHEJ) and alternative end joining (A-EJ), are involved in V(D)J recombination and chromosome translocation. Previous studies reported distinct repair mechanisms for chromosome translocation, with NHEJ involved in human and A-EJ in mice predominantly. NHEJ depends on DNA-PKcs, a critical partner in synapsis formation and downstream component activation. While DNA...

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Literature Corpus work: 49939d4f-7d1a-56a6-a26d-989342b37bbc
DOI: 10.1101/2023.12.30.573736

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