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DNA Substrate Dependence of p53-Mediated Regulation of Double-Strand Break Repair

1 Sept 2002

Abstract excerpt

DNA double-strand breaks (DSBs) arise spontaneously after the conversion of DNA adducts or single-strand breaks by DNA repair or replication and can be introduced experimentally by expression of specific endonucleases. Correct repair of DSBs is central to the maintenance of genomic integrity in mammalian cells, since errors give rise to translocations, deletions, duplications, and expansions, which accelerate the...

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PMID: 12167722
DOI: 10.1128/mcb.22.17.6306-6317.2002

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