Article
Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments.
Blood - 15 Sept 2004
Morii Eiichi, Oboki Keisuke, Ishihara Katsuhiko, Jippo Tomoko, Hirano Toshio, Kitamura Yukihiko
Abstract excerpt
The mutant tg/tg mice, which do not express mi transcription factor (MITF), lack mast cells in most tissues. Since MITF is expressed in both mast cells and tissues where mast cells develop, there is a possibility that the tg/tg mice may show abnormalities in both mast cell precursors and tissue environments. We examined this possibility by bone marrow and skin transplantation. When bone marrow cells of tg/tg mice...
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