Article
Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.
The American journal of pathology - 1 Oct 1994
Isozaki K, Tsujimura T, Nomura S, Morii E, Koshimizu U, Nishimune Y, Kitamura Y
Abstract excerpt
The mi locus of mice encodes a novel member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called mi factor). In addition to microphthalmus, osteopetrosis, and lack of melanocytes, mice of mi/mi genotype are deficient in mast cells. Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.