Article
Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.
The American journal of pathology - 1 Oct 1994
Isozaki K, Tsujimura T, Nomura S, Morii E, Koshimizu U, Nishimune Y, Kitamura Y
Abstract excerpt
The mi locus of mice encodes a novel member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called mi factor). In addition to microphthalmus, osteopetrosis, and lack of melanocytes, mice of mi/mi genotype are deficient in mast cells. Since the c-kit...
Topics
- Animals
- Animals, Newborn
- Erythroid Precursor Cells
- Fetus
- Gene Expression
- Genotype
- Germ Cells
- Male
- Mast Cells
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Neurons
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- RNA, Messenger
- Receptor Protein-Tyrosine Kinases
- Receptors, Colony-Stimulating Factor