Distribution of mast cells within the mouse heart and its dependency on Mitf

Abstract excerpt

• The distribution of cardiac mast cells in mice differs from humans and dogs. • This is important since mice are the most widely used genetic model for human pathology. • Loss-of-function mutation in the Mitf gene leads to near-complete lack of cardiac mast cells. • Loss of a single Mitf allele is sufficient for relative mast cell deficiency. Although mast cell distribution has been described in both human and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
• Share to Mast cells and histamine
• Share to melanin and skin pigmentation