Article
Effect of MITF on mast cell differentiation.
Molecular immunology - 1 Sept 2002
Kitamura Yukihiko, Morii Eiichi, Jippo Tomoko, Ito Akihiko
Abstract excerpt
The mi transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factor and encoded by the mi locus of mice. Double gene dose of mutant allele at the mi locus results the decrease of mast cells and phenotypic abnormalities of mast cells. Various mutations have been reported at the mi locus. We divided them to null and inhibitory mutations. The tg is a typical null mutation...
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