Article
Different effect of various mutant MITF encoded by mi, Mior, or Miwh allele on phenotype of murine mast cells.
Blood - 15 Jun 1999
Kim D K, Morii E, Ogihara H, Lee Y M, Jippo T, Adachi S, Maeyama K, Kim H M, Kitamura Y
Abstract excerpt
The mi locus encodes a member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called MITF). Mutant alleles of mi, Mior, and Miwh are deletion or point mutation of the basic domain by which MITF binds DNA. The basic domain also has nuclear localization potential. In the present study, we compared the mast cell abnormalities of Mior/Mior and Miwh/Miwh mice with those...
Topics
- Alleles
- Animals
- Animals, Suckling
- Cells, Cultured
- DNA
- DNA-Binding Proteins
- Helix-Loop-Helix Motifs
- In Situ Hybridization
- Leucine Zippers
- Mast Cells
- Mice
- Mice, Inbred C57BL
- Microphthalmia-Associated Transcription Factor
- Mutation