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Article

Different effect of various mutant MITF encoded by mi, Mior, or Miwh allele on phenotype of murine mast cells.

Blood - 15 Jun 1999

Kim D K, Morii E, Ogihara H, Lee Y M, Jippo T, Adachi S, Maeyama K, Kim H M, Kitamura Y

Abstract excerpt

The mi locus encodes a member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called MITF). Mutant alleles of mi, Mior, and Miwh are deletion or point mutation of the basic domain by which MITF binds DNA. The basic domain also has nuclear localization potential. In the present study, we compared the mast cell abnormalities of Mior/Mior and Miwh/Miwh mice with those...

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Identifiers

PMID: 10361115

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different effect of various mutant MITF encoded by mi, Mior, or Miwh allele on phenotype of murine mast cells.PMID 10361115Read ↗

Dual abnormal effects of mutant MITF encoded by Mi(wh) allele on mouse mast cells: decreased but recognizable transactivation and inhibition of transactivation.Semantic proximity Read ↗

Deficient transcription of mouse mast cell protease 4 gene in mutant mice of mi/mi genotype.Semantic proximity Read ↗

Inhibitory effect of the transcription factor encoded by the mi mutant allele in cultured mast cells of mice.Semantic proximity Read ↗

Effect of MITF on mast cell differentiation.Semantic proximity Read ↗

Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells.Semantic proximity Read ↗

Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.Semantic proximity Read ↗

Impaired expression of integrin alpha-4 subunit in cultured mast cells derived from mutant mice of mi/mi genotype.Semantic proximity Read ↗

Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene.Semantic proximity Read ↗

Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells.Semantic proximity Read ↗

Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of miceSemantic proximity Read ↗

Strain-dependent inhibitory effect of mutant mi-MITF on cytotoxic activities of cultured mast cells and natural killer cells of mice.Semantic proximity Read ↗

Molecular mechanisms of mast cell development.Semantic proximity Read ↗

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