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Article

Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells.

Blood - 15 Feb 2003

Morii Eiichi, Oboki Keisuke, Jippo Tomoko, Kitamura Yukihiko

Abstract excerpt

The mi transcription factor (MITF) is a basic-helix-loop-helix leucine zipper transcription factor and is encoded by mi locus. The mi/mi mutant mice showed a significant decrease of skin mast cells in C57BL/6 (B6) genetic background but not in WB genetic background. Kit ligand (KitL) is the most important growth factor for development of mast cells, and the decrease of skin mast cells in B6-mi/mi mice was...

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Source

Identifiers

PMID: 12393515
DOI: 10.1182/blood-2002-07-2213

Genes

KIT
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells.PMID 12393515Read ↗

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Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments.Semantic proximity Read ↗

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Deficient transcription of mouse mast cell protease 4 gene in mutant mice of mi/mi genotype.Semantic proximity Read ↗

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Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells.Semantic proximity Read ↗

Dual abnormal effects of mutant MITF encoded by Mi(wh) allele on mouse mast cells: decreased but recognizable transactivation and inhibition of transactivation.Semantic proximity Read ↗

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