Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms of mast cell development.

Immunology and allergy clinics of North America - 1 Aug 2006

Kitamura Yukihiko, Oboki Keisuke, Ito Akihiko

Abstract excerpt

Mast cells are progeny of multipotential hematopoietic stem cells (MHSCs). MHSCs commit to the mast cell lineage in the bone marrow, and the mast cell-committed progenitors leave the bone marrow, migrate in blood, invade connective or mucosal tissue, and then proliferate and differentiate to connective tissue-type or mucosal mast cell. GATA-1, GATA-2, and PU.1 transcription factors seem to be involved i the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokines
Share to KIT gene
Share to MITF gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast Cells

Share to Phenotype

Share to Receptors, Cytokine

Share to Stem Cells

Share to Transcription Factors

Source

Identifiers

PMID: 16931285
DOI: 10.1016/j.iac.2006.05.004

Genes

KIT
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms of mast cell development.PMID 16931285Read ↗

Molecular genetics and development of mast cells: implications for molecular medicine.Semantic proximity Read ↗

Mast cell ontogeny: From fetal development to life‐long health and diseaseSemantic proximity Read ↗

KIT as a master regulator of the mast cell lineageSemantic proximity Read ↗

New insights into "the riddle of the mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity.Semantic proximity Read ↗

Mast cell progenitors: Origin, development and migration to tissuesSemantic proximity Read ↗

The transcriptional program, functional heterogeneity, and clinical targeting of mast cellsSemantic proximity Read ↗

Mast cell transcription factors--regulators of cell fate and phenotype.Semantic proximity Read ↗

Developmental Origin and Functional Specialization of Mast Cell SubsetsSemantic proximity Read ↗

The ingenious mast cell: Contemporary insights into mast cell behavior and functionSemantic proximity Read ↗

Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine conceptsSemantic proximity Read ↗

Early development and functional properties of tryptase/chymase double-positive mast cells from human pluripotent stem cells.Semantic proximity Read ↗

Origin, maturation and recruitment of mast cell precursorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.