Article
Number of mast cells in the peritoneal cavity of mice: influence of microphthalmia transcription factor through transcription of newly found mast cell adhesion molecule, spermatogenic immunoglobulin superfamily.
The American journal of pathology - 1 Aug 2004
Morii Eiichi, Ito Akihiko, Jippo Tomoko, Koma Yu-Ichiro, Oboki Keisuke, Wakayama Tomohiko, Iseki Shoichi, Lamoreux M Lynn, Kitamura Yukihiko
Abstract excerpt
The mi (microphthalmia) locus of mice encodes a transcription factor, MITF. B6-tg/tg mice that do not express any MITF have white coats and small eyes. Moreover, the number of mast cells decreased to one-third that of normal control (+/+) mice in the skin of B6-tg/tg mice. No mast cells were detectable in the stomach, mesentery, and peritoneal cavity of B6-tg/tg mice. Cultured mast cells derived from B6-tg/tg...
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