Article
Mutation frequencies in murine keratinocytes as a function of carcinogenic status.
Molecular carcinogenesis - 1 Jun 2004
Christensen Laura A, Conti Claudio J, Fischer Susan M, Vasquez Karen M
Abstract excerpt
A link between genetic abnormalities and carcinogenesis is well established. It follows that a correlation exists between mutation frequency and malignant progression. We have determined the spontaneous and DNA damage-induced mutation frequencies for a series of cell lines derived from SENCAR mouse keratinocytes at various stages of malignant progression. Nontumorigenic mouse keratinocytes (3PC), papillomas...
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