Alterations of the p53 tumor suppressor gene during mouse skin tumor progression.

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Article

Alterations of the p53 tumor suppressor gene during mouse skin tumor progression.

Cancer research - 15 Dec 1991

Ruggeri B, Caamano J, Goodrow T, DiRado M, Bianchi A, Trono D, Conti C J, Klein-Szanto A J

Abstract excerpt

The two-stage murine skin tumorigenesis model is widely used to study the development of squamous cell neoplasias. We have investigated expression of the p53 and retinoblastoma tumor suppressor genes in eight murine skin tumor cell lines of varied histopathology and malignant potential, in seven...

Topics

Animals
Base Sequence
Blotting, Northern
Blotting, Southern
Carcinogens
Gene Expression
Genes, Retinoblastoma
Genes, p53
Mice
Molecular Sequence Data
Mutation
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Precipitin Tests

RNA, Messenger

RNA, Neoplasm

Skin Neoplasms

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1742735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1742735-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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