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Article

Alterations of the p53 tumor suppressor gene during mouse skin tumor progression.

Cancer research - 15 Dec 1991

Ruggeri B, Caamano J, Goodrow T, DiRado M, Bianchi A, Trono D, Conti C J, Klein-Szanto A J

Abstract excerpt

The two-stage murine skin tumorigenesis model is widely used to study the development of squamous cell neoplasias. We have investigated expression of the p53 and retinoblastoma tumor suppressor genes in eight murine skin tumor cell lines of varied histopathology and malignant potential, in seven in vivo-derived clones from these cell lines, and in 39 primary short-term cultures of similarly induced skin tumors at...

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PMID: 1742735

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