Article
Tissue specificity of spontaneous point mutations in lambda supF transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 1996
Leach E G, Narayanan L, Havre P A, Gunther E J, Yeasky T M, Glazer P M
Abstract excerpt
Transgenic mice carrying multiple copies of a recoverable lambda phage shuttle vector carrying the supF mutation reporter gene (lambda supF) were constructed for the purpose of studying mutagenesis in a whole animal. Spontaneous mutations in rescued supF target genes from mouse liver and skin were analyzed. The mutation frequency was similar in both tissues (in the range of 2 x 10(-5)), but the spectrum of point...
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