Article
Mutation spectra resulting from carcinogenic exposure: from model systems to cancer-related genes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer - 1 Jan 1998
Dogliotti E, Hainaut P, Hernandez T, D'Errico M, DeMarini D M
Abstract excerpt
The events leading to cancer are complex and interactive. Alteration of cancer genes, such as the tumor suppressor gene p53, plays a central role in this process. Analysis of the frequency, type and site of mutations in important cancer-related genes may provide clues to the identification of etiological factors and sources of exposure. In this chapter we have selected a few examples of environmental human...
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