Article
Simulated solar light-induced p53 mutagenesis in SKH-1 mouse skin: a dose-response assessment.
Molecular carcinogenesis - 1 Aug 2008
Verkler Tracie L, Delongchamp Robert R, Miller Barbara J, Webb Peggy J, Howard Paul C, Parsons Barbara L
Abstract excerpt
Sunlight and ultraviolet-induced mutation of the p53 gene is a frequent, possibly obligate step in skin cancer development, making quantitative measurement of p53 mutation an ideal biomarker for sunlight-induced skin carcinogenesis. To understand how the appearance of p53 mutation relates to skin...
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