Article
Spontaneous mutation spectra in supF: comparative analysis of mammalian cell line base substitution spectra.
Mutagenesis - 1 Nov 2001
Lewis P D, Harvey J S, Waters E M, Skibinski D O, Parry J M
Abstract excerpt
The last decade has seen a dramatic accumulation of mutation data from reporter genes utilized in mutagenesis experiments involving DNA reactive agents allowing comparisons for the mutagenic potential between many different mutagens. When analysing chemically induced mutation spectra it is important to establish the potential spontaneous background before drawing conclusions concerning specific chemically induced...
Topics
- Animals
- Base Sequence
- COS Cells
- Cell Line, Transformed
- Chlorocebus aethiops
- Cytosine
- DNA Mutational Analysis
- Genes, Suppressor
- Guanine
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- RNA, Transfer