Article
FLT3-activating mutations are associated with poor prognostic features in AML at diagnosis but they are not an independent prognostic factor.
The hematology journal : the official journal of the European Haematology Association - 1 Jan 2004
Chillón M Carmen, Fernández Carina, García-Sanz Ramón, Balanzategui Ana, Ramos Fernando, Fernández-Calvo Javier, González Marcos, Miguel Jesús F San
Abstract excerpt
FLT3: gene alterations (internal tandem duplications - ITDs - and D835 mutations) are thought to be associated with poor-risk acute myeloid leukemia (AML). However, not all studies confirm this association, so it is still a matter of debate. Moreover, their association with other molecular abnormalities is less studied. We have investigated the presence of FLT3-ITD and D835 mutations in AML patients and their...
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