Article
Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol.
Leukemia - 1 Nov 2002
Noguera N I, Breccia M, Divona M, Diverio D, Costa V, De Santis S, Avvisati G, Pinazzi M B, Petti M C, Mandelli F, Lo Coco F
Abstract excerpt
Alterations in the FLT3 gene, including internal tandem duplications (ITDs) and D835 mutations occur frequently in acute myelogenous leukemia. We investigated the prevalence and clinico-biological correlations of FLT3 ITDs and D835 mutations in 90 patients with acute promyelocytic leukemia (APL) receiving the AIDA protocol. Twenty patients in which both presentation and relapse material was available were...
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