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Article

FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact.

British journal of haematology - 1 May 2004

Au Wing Y, Fung Alvin, Chim Chor S, Lie Albert K, Liang Raymond, Ma Edmond S K, Chan Cheuk H, Wong Kit F, Kwong Yok L

Abstract excerpt

FLT-3 aberrations that occur as an internal tandem duplication (ITD) or a mutation at the activation-loop position 835, D835, are common in acute promyelocytic leukaemia (APL). We investigated the clinicopathological associations and prognostic impact of FLT-3 aberrations in a cohort of APL patients. FLT-3 exons 11 and 12 were amplified by polymerase chain reaction (PCR), and the ITD was recognized as an increase...

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Identifiers

PMID: 15142116
DOI: 10.1111/j.1365-2141.2004.04935.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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