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Article

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia.

Blood - 1 Dec 2005

Gale Rosemary E, Hills Robert, Pizzey Arnold R, Kottaridis Panagiotis D, Swirsky David, Gilkes Amanda F, Nugent Elizabeth, Mills Kenneth I, Wheatley Keith, Solomon Ellen, Burnett Alan K, Linch David C, Grimwade David

Abstract excerpt

The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors. We studied 203 patients with PML-RARA-positive APL; 43% of the patients had an FLT3 mutation (65 internal tandem duplications [ITDs], 19 D835/I836, 4 ITD+D835/I836). Both mutations were associated with...

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Source

Identifiers

PMID: 16105978
DOI: 10.1182/blood-2005-04-1746

Genes

FLT3
PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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