Article
Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia.
Haematologica - 1 Jan 2003
Moreno Isabel, Martín Guillermo, Bolufer Pascual, Barragán Eva, Rueda Eva, Román José, Fernández Pascual, León Pilar, Mena Armando, Cervera José, Torres Antonio, Sanz Miguel A
Abstract excerpt
BACKGROUND AND OBJECTIVES: Cytogenetics is the most important prognostic factor in acute myeloid leukemia (AML). However, a high proportion of patients show normal or intermediate-risk karyotypes. In these patients, other determinants could help to identify those with a higher risk of relapse. Recently, internal tandem duplications (ITD) and D835 mutations in FLT3 tyrosine kinase receptor have been shown to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.