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Article

Genetic pathways to colorectal cancer.

Mutation research - 2 Nov 2009

Lea Isabel A, Jackson Marcus A, Dunnick June K

Abstract excerpt

The colorectal cancer paradigm explains how genetic and histological changes lead normal epithelial cell to transform into pre-malignant adenomas then progress to malignant carcinomas. Using the Genetic Alterations in Cancer Knowledge System intragenic allele loss and gene mutation data from approximately 9000 colorectal tumors were compared to the model of colorectal tumor development. The distribution of...

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Source

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Identifiers

PMID: 19576232
DOI: 10.1016/j.mrfmmm.2009.06.011
PMCID: PMC2768054

Genes

APC
BRAF
HRAS
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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