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Molecular genetics of colorectal carcinoma.

Cancer - 1 Sept 1992

Hamilton S R

Abstract excerpt

The molecular genetics of colorectal carcinoma are among the best understood of any common human cancer. Reported molecular genetic abnormalities involve tumor-suppressor genes that undergo inactivation (e.g., apc, mcc, dcc, p53, and possibly genes on chromosomes 8p, 1p, and 22q) and dominant-acting oncogenes (e.g., ras, src, and myc). Multiple clonal genetic abnormalities accumulate during the development of...

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PMID: 1511369
DOI: 10.1002/1097-0142(19920901)70:3+<1216::aid-cncr2820701505>3.0.co;2-f

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