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Article

Suppressor gene alterations in the colorectal adenoma-carcinoma sequence.

Journal of cellular biochemistry. Supplement - 1 Jan 1992

Cho K R, Vogelstein B

Abstract excerpt

Tumorigenesis is thought to be a multistep process in which genetic alterations accumulate to bring about the neoplastic phenotype. Colorectal tumors appear to arise as a result of the mutational activation of oncogenes coupled with the inactivation of several tumor suppressor genes. We have found frequent allelic deletions of specific portions of chromosomes 5, 17, and 18 which presumably harbor suppressor...

Topics

Adenoma
Carcinoma
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 18
Colonic Neoplasms
Gene Deletion
Genes, Tumor Suppressor
Genes, p53
Humans
Mutation
Rectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1469893
DOI: 10.1002/jcb.240501124

Genes

APC
FAP
MCC
DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1469893-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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