Article
The cellular and molecular pathogenesis of colorectal cancer.
Gastroenterology clinics of North America - 1 Dec 1996
Carethers J M
Abstract excerpt
The development of colorectal neoplasia originates from normal colonic mucosa, progresses to the adenomatous polyp, and later may evolve into carcinoma. This procession of histologic change can be defined by a series of successive waves of clonal expansion that contain certain genetic alterations...
Topics
- Adenomatous Polyposis Coli
- Alleles
- Colorectal Neoplasms
- Disease Progression
- Gene Deletion
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Microsatellite Repeats
- Oncogenes