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Article

Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.

Seminars in cancer biology - 1 Jun 1993

Williams A C, Browne S J, Manning A M, Hague A, van der Stappen J W, Paraskeva C

Abstract excerpt

Colorectal carcinogenesis is a complex multistage process and occurs through the accumulation of gene mutations in both oncogenes and tumour suppressor genes. Frequent genetic abnormalities include mutation of the familial adenomatous polyposis (APC) and/or the mutated in colorectal cancer (MCC) genes on chromosome 5q21, activation of K-ras and loss of the tumour suppressor genes p53 and DCC (deleted in...

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Identifiers

PMID: 8318691

Genes

APC
DCC
MCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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