Molecular biology of colorectal cancer.

doi:10.1016/s0147-0272(97)80003-7

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Article

Molecular biology of colorectal cancer.

Current problems in cancer - 1 Jan 2000

Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, Couture J

Abstract excerpt

Colorectal cancer is a significant cause of morbidity and mortality in Western populations. This cancer develops as a result of the pathologic transformation of normal colonic epithelium to an adenomatous polyp and ultimately an invasive cancer. The multistep progression requires years and possibly decades and is accompanied by a number of recently characterized genetic alterations. Mutations in two classes of...

Topics

Colorectal Neoplasms
DNA, Neoplasm
Disease Progression
Genes, Tumor Suppressor
Genetic Markers
Genetic Testing
Humans
Models, Genetic
Molecular Biology
Mutation
Oncogenes
Pedigree
Risk Assessment

Source

Open in PubMed

Identifiers

PMID: 9438104
DOI: 10.1016/s0147-0272(97)80003-7

Genes

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