Article
Molecular biology of colorectal cancer.
Current problems in cancer - 1 Jan 2000
Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, Couture J
Abstract excerpt
Colorectal cancer is a significant cause of morbidity and mortality in Western populations. This cancer develops as a result of the pathologic transformation of normal colonic epithelium to an adenomatous polyp and ultimately an invasive cancer. The multistep progression requires years and possibly decades and is accompanied by a number of recently characterized genetic alterations. Mutations in two classes of...
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