Article
Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2004
Gemmati Donato, Ongaro Alessia, Scapoli Gian L, Della Porta Matteo, Tognazzo Silvia, Serino Maria L, Di Bona Eros, Rodeghiero Francesco, Gilli Giuseppe, Reverberi Roberto, Caruso Angelo, Pasello Michela, Pellati Agnese, De Mattei Monica
Abstract excerpt
Folate and methionine metabolism is involved in DNA synthesis and methylation processes. Polymorphisms in the genes of folate metabolism enzymes have been associated with some forms of cancer. In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G), and methionine synthase reductase (MTRR A66G) genes...
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