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Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis based on 28 case-control studies.

Leukemia & lymphoma - 1 Oct 2011

Tong Na, Sheng Xiaojing, Wang Meilin, Fang Yongjun, Shi Danni, Zhang Zhizhong, Zhang Zhengdong

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is involved in DNA methylation and nucleotide synthesis. Accumulated evidence has demonstrated that C677T and A1298C polymorphisms of the MTHFR gene are associated with acute lymphoblastic leukemia (ALL) risk, but the results have been inconclusive. To determine a more precise estimation, we performed a meta-analysis of 28 studies with 4240 cases and 9289 controls. We...

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Identifiers

PMID: 21702646
DOI: 10.3109/10428194.2011.589545

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis based on 28 case-control studies.PMID 21702646Read ↗

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The association between MTHFR gene C677T polymorphism and ALL risk based on a meta-analysis involving 17,469 subjects.Semantic proximity Read ↗

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