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Methylenetetrahydrofolate reductase C677T genetic polymorphisms and risk of leukaemia among the North Indian population.

Cancer epidemiology - 1 Aug 2012

Hussain Syed Rizwan, Naqvi Hena, Raza Syed Tasleem, Ahmed Faisal, Babu Sunil G, Kumar Ashutosh, Zaidi Zeashan Haider, Mahdi Farzana

Abstract excerpt

BACKGROUND: Leukaemia is a heterogeneous disease in which haematopoietic progenitor cells acquire genetic lesions that lead to a block in differentiation, increased self-renewal, and unregulated proliferation. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), involved in folate metabolism, plays a crucial role in cells because folate availability is important for DNA integrity. The aim of this...

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Identifiers

PMID: 22441130
DOI: 10.1016/j.canep.2012.02.008

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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