Article
Clinical significance of periodic detection of hepatitis B virus YVDD mutation by ultrasensitive real-time amplification refractory mutation system quantitative PCR during lamivudine treatment in patients with chronic hepatitis B.
Journal of medical microbiology - 1 Mar 2015
Zeng Yongbin, Yang Bin, Wu Yingying, Chen Jing, Shang Hongyan, Chen Xiao, Su Mingkuan, Wu Songhang, Lin Jinpiao, Ou Qishui
Abstract excerpt
Monitoring hepatitis B virus (HBV) mutants periodically during nucleoside analogue treatment is of great clinical significance, particularly in persistently HBV DNA-positive patients. However, few studies have investigated the dynamic changes of HBV YMDD (Tyr-Met-Asp-Asp) and YVDD (Tyr-Val-Asp-Asp) populations in chronic hepatitis B (CHB) patients whilst undergoing lamivudine (LMV) treatment. In this study, we...
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