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Article

Ultrasensitive genotypic detection of antiviral resistance in hepatitis B virus clinical isolates.

Antimicrobial agents and chemotherapy - 1 Jul 2009

Fang Jie, Wichroski Michael J, Levine Steven M, Baldick Carl J, Mazzucco Charles E, Walsh Ann W, Kienzle Bernadette K, Rose Ronald E, Pokornowski Kevin A, Colonno Richard J, Tenney Daniel J

Abstract excerpt

Amino acid substitutions that confer reduced susceptibility to antivirals arise spontaneously through error-prone viral polymerases and are selected as a result of antiviral therapy. Resistance substitutions first emerge in a fraction of the circulating virus population, below the limit of detection by nucleotide sequencing of either the population or limited sets of cloned isolates. These variants can expand...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19433559
DOI: 10.1128/AAC.00130-09
PMCID: PMC2704686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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