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Article

TP53 polymorphism may contribute to genetic susceptibility to develop Hashimoto's thyroiditis.

Journal of endocrinological investigation - 1 Nov 2015

Ruggeri R M, Vicchio T M, Giovinazzo S, Certo R, Alibrandi A, Trimarchi F, Benvenga S, Trovato M

Abstract excerpt

PURPOSE: p53, which is encoded by the tumor suppressor gene TP53, plays a crucial role in the regulation of mechanisms of cell cycle arrest and apoptosis. Some SNPs of TP53, involving a different apoptotic ability of p53, have been associated with increased susceptibility to develop autoimmune diseases as well as cancer. We investigated the genotypic distribution of TP53 exon 4 SNPs in a cohort of Caucasian...

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PMID: 25935255
DOI: 10.1007/s40618-015-0292-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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