Article
Convergent evidence of the contribution of TP53 genetic variation (Pro72Arg) to metabolic activity and white matter volume in the frontal lobe in schizophrenia patients.
NeuroImage - 1 May 2011
Molina Vicente, Papiol Sergi, Sanz Javier, Rosa Araceli, Arias Bárbara, Fatjó-Vilas Mar, Calama Julia, Hernández Ana I, Bécker Joemir, Fañanás Lourdes
Abstract excerpt
Abnormalities in white matter (WM) volumes and integrity in schizophrenia, together with post-mortem studies showing reduced expression of oligodendrocyte/myelination genes and apoptotic processes taking place in oligodendrocytes, suggest the interest of major regulators of apoptosis as candidate genes for some features related to myelin integrity in schizophrenia. Protein p53, encoded by TP53 gene, has a central...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.