Article
Association study between P53 and P73 gene polymorphisms and the sporadic late-onset form of Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2009
Scacchi Renato, Gambina Giuseppe, Moretto Giuseppe, Corbo Rosa Maria
Abstract excerpt
An important pathological aspect of Alzheimer's disease (AD) is the apoptosis of neuronal and glial cells. Two members of the same protein family that regulates many genes involved in apoptosis are P53 and the heterologue P73. One single nucleotide polymorphism (SNP) in the gene encoding P53 (Arg72Pro, RS1042522), one dinucleotide polymorphism (G4C14-to-A4T14, RS 2273953, RS1801173) in the gene encoding P73, and...
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