Article
Tumor suppressor gene TP53 is genetically associated with schizophrenia in the Chinese population.
Neuroscience letters - 14 Oct 2004
Yang Yifeng, Xiao Zeping, Chen Weixiong, Sang Hong, Guan Yousheng, Peng Yanwei, Zhang Diran, Gu Zhongzhong, Qian Mincai, He Guang, Qin Wei, Li Dawei, Gu Niufan, He Lin
Abstract excerpt
Schizophrenia is a debilitating mental disorder. The TP53 tumor suppressor gene, encoding a phosphoprotein, is a key element in maintaining genomic stability and cell apoptosis. Recently, reduced risk of cancer in patients of schizophrenia has been reported. Some evidence also suggests the possible implication of TP53 in neurodevelopment. In order to examine the role of the TP53 gene in the pathogenesis of...
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