Article
Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.
Lancet (London, England) - 4 May 1996
Satsangi J, Welsh K I, Bunce M, Julier C, Farrant J M, Bell J I, Jewell D P
Abstract excerpt
BACKGROUND: Despite strong evidence implicating immune dysfunction and genetic predisposition in the pathogenesis of the chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis, the importance of the genes of the major histocompatibility complex remains uncertain. We have inves...
Topics
- Adult
- Alleles
- Colitis, Ulcerative
- Crohn Disease
- Female
- Genes, MHC Class II
- Genetic Linkage
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains