Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.

doi:10.1093/ibd/izx084

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Article

Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.

Inflammatory bowel diseases - 19 Mar 2018

Venkateswaran Suresh, Prince Jarod, Cutler David J, Marigorta Urko M, Okou David T, Prahalad Sampath, Mack David, Boyle Brendan, Walters Thomas, Griffiths Anne, Sauer Cary G, LeLeiko Neal, Keljo David, Markowitz James, Baker Susan S, Rosh Joel, Pfefferkorn Marian, Heyman Melvin B, Patel Ashish, Otley Anthony, Baldassano Robert, Noe Joshua, Rufo Paul, Oliva-Hemker Maria, Davis Sonia, Zwick Michael E, Gibson Greg, Denson Lee A, Hyams Jeffrey, Kugathasan Subra

Abstract excerpt

Background: The genetic contributions to pediatric onset ulcerative colitis (UC), characterized by severe disease and extensive colonic involvement, are largely unknown. In adult onset UC, Genome Wide Association Study (GWAS) has identified numerous loci, most of which have a modest susceptibility risk (OR 0.84-1.14), with the exception of the human leukocyte antigen (HLA) region on Chromosome 6 (OR 3.59)....

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PMID: 29562276
DOI: 10.1093/ibd/izx084
PMCID: PMC6350448

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