Article

An extremes of phenotype approach confirms significant genetic heterogeneity in patients with ulcerative colitis

2021-10-12

Abstract excerpt

Ulcerative colitis (UC) is a major form of inflammatory bowel disease with increasing global incidence. There is significant phenotypic heterogeneity defined by a range of clinical variables including age of onset and disease extent. Clinical outcomes range from long-term remission on minimal therapy to surgical resection. Close to 70% of UC risk can be attributed to genetics and understanding the genetic mechanis...

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Literature Corpus work: bf91f3d0-38e4-5b67-8654-77c41db53062
DOI: 10.1101/2021.10.04.462982

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