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Article

DNA repair defects channel interstrand DNA cross-links into alternate recombinational and error-prone repair pathways.

The Journal of biological chemistry - 27 Aug 2004

Saffran Wilma A, Ahmed Shaila, Bellevue Sherly, Pereira Gillian, Patrick Teleka, Sanchez Wendy, Thomas Sandra, Alberti Marie, Hearst John E

Abstract excerpt

The repair of psoralen interstrand cross-links in the yeast Saccharomyces cerevisiae involves the DNA repair groups nucleotide excision repair (NER), homologous recombination (HR), and post-replication repair (PRR). In repair-proficient yeast cells cross-links induce double-strand breaks, in an NER-dependent process; the double-strand breaks are then repaired by HR. An alternate error-prone repair pathway...

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Source

Identifiers

PMID: 15213235
DOI: 10.1074/jbc.M402323200

Genes

RAD1
RAD18
RAD51
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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