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Article

Acquired resistance to reoviral oncolysis in Ras-transformed fibrosarcoma cells.

Oncogene - 14 Jun 2007

Kim M, Egan C, Alain T, Urbanski S J, Lee P W, Forsyth P A, Johnston R N

Abstract excerpt

Reovirus shows considerable potential as an oncolytic agent for Ras-activated tumors and is currently in clinical trials. Here we ask whether such tumor cell lines can acquire resistance to reoviral oncolysis. We challenged human HT1080 fibrosarcoma cells that carry a Ras mutation by prolonged exposure to reovirus, thereby yielding highly virus-resistant HTR1 cells. These cells are persistently infected with...

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Identifiers

PMID: 17213803
DOI: 10.1038/sj.onc.1210189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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