Article
Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice.
The Journal of rheumatology - 1 Aug 1994
Lemaire R, Flipo R M, Monté D, Dupressoir T, Duquesnoy B, Cesbron J Y, Janin A, Capron A, Lafyatis R
Abstract excerpt
OBJECTIVE: To understand the intracellular signals leading to transformed-like growth of synovial fibroblast-like cells from patients with rheumatoid arthritis (RA). METHODS: Cell lines stably transfected with one or both of 2 complementary oncogenes, the SV40 large T antigen and the ras oncogene...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Arthritis, Rheumatoid
- Base Sequence
- Cathepsin L
- Cathepsins
- Cell Transformation, Neoplastic
- Cells, Cultured
- Collagenases
- Cysteine Endopeptidases
- DNA
- Endopeptidases
- Fibroblasts
- Genes, ras