Article
Cathepsin L increased level upon Ras mutants expression: the role of p38 and p44/42 MAPK signaling pathways.
Molecular and cellular biochemistry - 1 Oct 2010
Urbanelli Lorena, Trivelli Francesco, Ercolani Luisa, Sementino Eleonora, Magini Alessandro, Tancini Brunella, Franceschini Raffaella, Emiliani Carla
Abstract excerpt
The involvement of Ras and three major Ras effectors, Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide exchange factor in the regulation of lysosomal proteases cathepsin L and B in human fibroblasts was compared. We found that cathepsin L cell content was increased by active Ras overexpression through Raf- and PI3K-mediated signaling pathways, while cathepsin B processing was altered by active...
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