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Article

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

Oncogene - 1 Dec 1990

Garcia M, Derocq D, Pujol P, Rochefort H

Abstract excerpt

Cathepsin D, an aspartic lysosomal proteinase, is overexpressed by breast cancer cells and highly correlated with the occurrence of metastasis in patients. We used an adenovirus transformed rat cell line that does not secrete cathepsin D, to study the consequences of transfecting human cathepsin D cDNA. Overexpression of human cathepsin D in stable transfectant clones, results in higher initial growth rates in...

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Identifiers

PMID: 2284099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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