Article
Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.
Oncogene - 1 Dec 1990
Garcia M, Derocq D, Pujol P, Rochefort H
Abstract excerpt
Cathepsin D, an aspartic lysosomal proteinase, is overexpressed by breast cancer cells and highly correlated with the occurrence of metastasis in patients. We used an adenovirus transformed rat cell line that does not secrete cathepsin D, to study the consequences of transfecting human cathepsin...
Topics
- Animals
- Cathepsin D
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Liver Neoplasms
- Mice
- Mice, Nude
- Neoplasm Metastasis
- Phenotype