Article
Transient alterations in the expression of protease and extracellular matrix genes during metastatic lung colonization by H-ras-transformed 10T1/2 fibroblasts.
Cancer research - 1 Jul 1990
Gingras M C, Jarolim L, Finch J, Bowden G T, Wright J A, Greenberg A H
Abstract excerpt
It has been proposed that tumor progression is a selective process and that only a minority of tumor cells survive this selection because they possess the phenotypic traits necessary for metastasis and organ colonization. Both proteases and extracellular matrix proteins have been implicated in invasion and metastasis formation. To examine the nature of the selection process, we transformed 10T1/2 fibroblasts with...
Topics
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Endopeptidases
- Extracellular Matrix
- Fibrosarcoma
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Lung Neoplasms
- Mice