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Article

Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus.

Cancer research - 15 May 2004

Maley Carlo C, Galipeau Patricia C, Li Xiaohong, Sanchez Carissa A, Paulson Thomas G, Reid Brian J

Abstract excerpt

Neoplastic progression is an evolutionary process characterized by genomic instability and waves of clonal expansions carrying genetic and epigenetic lesions to fixation (100% of the cell population). However, an evolutionarily neutral lesion may also reach fixation if it spreads as a hitchhiker on a selective sweep. We sought to distinguish advantageous lesions from hitchhikers in the premalignant condition...

Read the complete abstract on PubMed

Topics

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Share to Barrett Esophagus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Esophageal Neoplasms

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Source

Identifiers

PMID: 15150093
DOI: 10.1158/0008-5472.CAN-03-3249

Genes

CDKN2A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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