Article
p16 mutation spectrum in the premalignant condition Barrett's esophagus.
PloS one - 1 Jan 2008
Paulson Thomas G, Galipeau Patricia C, Xu Lianjun, Kissel Heather D, Li Xiaohong, Blount Patricia L, Sanchez Carissa A, Odze Robert D, Reid Brian J
Abstract excerpt
BACKGROUND: Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions. METHODS AND FINDINGS: We have determined the p16 mutation spectrum for a cohort of 304 patients with Barrett's esophagus, a...
Topics
- Adult
- Aged
- Aged, 80 and over
- Barrett Esophagus
- Clone Cells
- Cohort Studies
- DNA Mutational Analysis
- Esophagus
- Exons
- Female
- Genes, p16