Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of heterozygosity on chromosome 17p predicts neoplastic progression in Barrett's esophagus.

Journal of gastroenterology and hepatology - 1 Jun 2003

Dolan Kevin, Morris Anthony I, Gosney John R, Field John K, Sutton Robert

Abstract excerpt

BACKGROUND AND AIM: Endoscopic surveillance for adenocarcinoma in patients with Barrett's esophagus is costly, with one cancer detected every 48-441 patient years of follow up. Genetic abnormalities, including loss of heterozygosity at sites of tumor suppressor genes, have been detected in malignant and premalignant Barrett's esophagus. The aim of this prospective study was to determine if loss of heterozygosity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Barrett Esophagus
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endoscopy, Gastrointestinal

Share to Esophageal Neoplasms

Share to Loss of Heterozygosity

Share to Metaplasia

Share to Statistics as Topic

Share to Survival Analysis

Source

Identifiers

PMID: 12753151
DOI: 10.1046/j.1440-1746.2003.03048.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity on chromosome 17p predicts neoplastic progression in Barrett's esophagus.PMID 12753151Read ↗

Clonal expansion and loss of heterozygosity at chromosomes 9p and 17p in premalignant esophageal (Barrett's) tissue.Semantic proximity Read ↗

Genetic Mechanisms of TP53 Loss of Heterozygosity in Barrett's Esophagus: Implications for Biomarker ValidationSemantic proximity Read ↗

Single nucleotide polymorphism-based genome-wide chromosome copy change, loss of heterozygosity, and aneuploidy in Barrett's esophagus neoplastic progression.Semantic proximity Read ↗

17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy.Semantic proximity Read ↗

Translation of an STR-based biomarker into a clinically compatible SNP-based platform for loss of heterozygosity.Semantic proximity Read ↗

Frequent loss of heterozygosity in the region including BRCA1 on chromosome 17q in squamous cell carcinomas of the esophagus.Semantic proximity Read ↗

Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at multiple sites.Semantic proximity Read ↗

Genomic analysis of Barrett's esophagus after ablative therapy: Persistence of genetic alterations at tumor suppressor lociSemantic proximity Read ↗

Molecular genetic analysis of surveillance biopsy samples from Barrett's mucosa--significance of sampling.Semantic proximity Read ↗

Loss of p53 in esophageal squamous cell carcinoma and the correlation with survival: analyses of gene mutations, protein expression, and loss of heterozygosity in Japanese patients.Semantic proximity Read ↗

Mutation analysis of the p53, APC, and p16 genes in the Barrett's oesophagus, dysplasia, and adenocarcinoma.Semantic proximity Read ↗

Genetic mechanisms in esophageal carcinogenesis: frequent deletion of 3p and 17p in premalignant lesions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.